Publications by Author Beau Peelle

Viruses as vehicles for growth, organization and assembly of materials

CE Flynn, SW Lee, BR Peelle, AM Belcher – Acta Materialia, 2003 – Elsevier
Viruses have been used as scaffolds for the peptide-directed synthesis of magnetic and semiconducting materials, and have been further exploited in the formation of nanowires and liquid crystals. Reviewed in this manuscript is the work of Douglas, Mann, Fraden,

Design criteria for engineering inorganic material-specific peptides

BR Peelle, EM Krauland, KD Wittrup, AM Belcher – Langmuir, 2005 – ACS Publications
Development of a fundamental understanding of how peptides specifically interact with inorganic material surfaces is crucial to furthering many applications in the field of nanobiotechnology. Herein, we report systematic study of peptide sequence-activity

Synthesis of monofunctionalized gold nanoparticles by Fmoc solid-phase reactions

KM Sung, DW Mosley, BR Peelle, S Zhang… – Journal of the …, 2004 – ACS Publications
In this communication, solid-phase reactions for the synthesis of Lys-monofunctionalized gold nanoparticles are described. A controlled and selective fabrication of linear nanoparticle arrays can be achieved through peptide linkage systems, and therefore it is

Genetically driven assembly of nanorings based on the M13 virus

KT Nam, BR Peelle, SW Lee, AM Belcher – Nano letters, 2004 – ACS Publications
One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti-streptavidin peptide and


Retrovirally delivered random cyclic peptide libraries yield inhibitors of interleukin-4 signaling in human B cells

…, CT Ohashi, AG Harder, GC Yam, W Li, B Peelle… – Journal of Biological …, 2002 – ASBMB
Abstract Inteins are polypeptide sequences found in a small set of primarily bacterial proteins that promote the splicing of flanking pre-protein sequences to generate mature protein products. Inteins can be engineered in a “split and inverted” configuration such

Intracellular protein scaffold-mediated display of random peptide libraries for phenotypic screens in mammalian cells

B Peelle, J Lorens, W Li, J Bogenberger, DG Payan… – Chemistry & biology, 2001 – Elsevier
Background: Mammalian cell screens of peptide libraries for changes in cellular phenotype may identify novel functional peptides and their cognate binding partners, and allow identification of signal transduction network members or proteins important in disease

Peptide tags for enhanced cellular and protein adhesion to single‐crystalline sapphire

EM Krauland, BR Peelle, KD Wittrup… – Biotechnology and …, 2007 – Wiley Online Library
Abstract In order to facilitate a novel means for coupling proteins to metal oxides, peptides were identified from a dodecamer peptide yeast surface display library that bound a model metal oxide material, the C, A, and R crystalline faces of synthetic sapphire (α-Al 2 O 3).

Probing the interface between biomolecules and inorganic materials using yeast surface display and genetic engineering

BR Peelle, EM Krauland, KD Wittrup, AM Belcher – Acta biomaterialia, 2005 – Elsevier
Although promising for biomimetic materials applications, polypeptides binding inorganic material surfaces and the mechanism of their function have been difficult to characterize. This paper reports sequence–activity relationships of peptides interfacing with

Characterization and use of green fluorescent proteins from Renilla mulleri and Ptilosarcus guernyi for the human cell display of functional peptides

B Peelle, TL Gururaja, DG Payan… – Journal of protein …, 2001 – Springer
Abstract Green fluorescent protein (GFP) is useful as an intracellular scaffold for the display of random peptide libraries in yeast. GFPs with a different sequence from Aequorea victoria have recently been identified from Renilla mulleri and Ptilosarcus gurneyi. To examine

Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library

…, SM Catalano, J McLaughlin, E Pali, B Peelle… – Chemistry & biology, 2003 – Elsevier
We have generated a random peptide library fused to GFP in a retroviral vector system and used this library to screen for peptides inhibiting tumor cell growth. Four unique peptide sequences were isolated that exhibited antiproliferative effects and that specifically